Some of Common Questions and Answers for Laboratory Technicians and Technologists.
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Questions 551 to 600
- Hydroxyurea:
- decreases nitric oxide
- increases neutrophil and monocytes
- inhibits DNA synthesis by acting as a ribonucleotide ✔
- reductase inhibitor
- Hydroxyurea increases the serum uric acid levels.
- True ✔
- False
- Decitabine increases the fetal hemoglobin production by inducing methylation of DNA and thus prevents the switch from gamma to beta-globin production.
- True
- False ✔
- Hypocupremia is seen in
- osetoporosis, nephrotic disease
- sprue, cliac disease
- cardiovascular disease, colon cancer
- All of the above ✔
- Wilsons disease can cause liver problems
- True ✔
- False
- What are the treatment options for wilson’s disease?
- Pencillamine
- Trientine
- Potassium disulfide
- Zinc
- All of Above ✔
- Aplasia can occur because of riboflavin deficiency?
- True ✔
- False
- Angular stomatitis.cheilosis is a symptom of vitamin B12 deficiency?
- True
- False ✔
- Antimalarial drugs and high dose birth control will increase riboflavin.
- True
- False ✔
- Which test can be used to detect hemolytic anemia ?
- Coombs test ✔
- Genetic testing
- Peripheral blood smear (PBS)
- Schilling test
- Which anemia is classified as not being able to use iron properly to synthesize hemoglobin because of a inherited cause.
- Iron deficiency anemia
- hypochromic anemia ✔
- aplastic anemia
- Apalstic anemia can be induced by drugs such as Litium, acetazolamide and aspirtin
- True ✔
- False
- This fatal disorder results from clot/thrombus formation in the blood ciruclation
- thromboembolism
- DVT
- PAD
- Pulmonary embolism
- All of the above ✔
- Homan’s sign is classified as pain behind the knee
- True ✔
- False
- Patients that are sensitive to aspirin can take:
- Sulfinpyrazone
- Clopidogrel
- Ticlopidine
- All of Above ✔
- What is the life span of RBC
- 200
- 120 ✔
- 100
- 80
- This drug can potentiate the effect of prostacyclins to antagonize platelet stickiness and therefore decreases platelet adhesion to thrombogenic surfaces.
- Sulfinpyrazone
- Dipyridamole ✔
- ticlopidine
- Which drug can be given as a prophylaxis for cadriovascular effects ?
- Ticlopidine
- Clopidogrel ✔
- dipyridamol ✔
- Which drug can increase intracellular levels of cAMP by inhibiting cyclic nucleotide phosphodiesterase ?
- Sildenafil ✔
- Ticlopidine
- Clopidogrel
- dipyridamol ✔
- Warfarin should be used with caution in the following:
- Alcoholic liver disease
- Gastrointestinal bleeding
- recent neurosugery
- Liver impairment ✔
- Isozymes of 2C can greatly effect warfarin
- True ✔
- False
- absolute lymphocytosis (>5000/mm^3) without adenopathy, hepatosplenomegaly, anemia, thrombocytopenia is what stage in CLL prognosis Scoring-Rai Staging System?
- Stage 0 ✔
- Stage I
- Stage II
- Stage III
- Stage IV
- Conventional treatment is ______ for Rai stage II
- Antibiotics
- chemotherapy ✔
- Antivirals
- rest
- In patients with low numbers of neoplastic cells, sometimes due to treatment, PCR to amplify DNA can improve sensitivity, and detect signs of relapse.
- True ✔
- False
- Chronic lymphocytic leukemia is most common leukemia in what kind of people? Slide 4
- young adults
- older adults ✔
- absolute lymphocytosis and thrombocytopenia( < 100,000/mm^3) with or without lymphadenopathy, hepatomegaly, splenomegaly, or anemia is what stage in CLL prognosis Scoring-Rai Staging System ?
- Stage 0
- Stage I
- Stage II
- Stage III
- Stage IV ✔
- Chronic Lymphocytic Leukemia is characterized by peripheral blood and bone marrow _____.
- lymphocytopenia
- lymphocytosis ✔
- Chronic Lymphocytic Leukemia is characterized by gradual accumulation of small mature ______ cells.
- T
- B ✔
- NK
- Which of the following is the most mature normoblast ?
- Orthochromic Normoblast ✔
- Basophilic Normoblast
- Pronormoblast
- Polychromatic Normoblast
- absolute lymphocytosis with either hepatomegaly or splenomegaly with or without lymphadenopathy is what stage in CLL prognosis Scoring-Rai Staging System ?
- Stage 0
- Stage I
- Stage II ✔
- Stage III
- Stage IV
- absolute lymphocytosis without lymphadenopathy without hepatosplenomegaly, anemia, or thrombocytopenia is what stage in CLL prognosis Scoring-Rai Staging System ?
- Stage 0
- Stage I ✔
- Stage II
- Stage III
- Stage IV
- IN Chronic Lymphocytic Leukemia the Lymphocyte appearance: small or slightly larger than normal, hyper-condensed(almost ________ appearing. nuclear chromatin patter, bare nuclei called “smudge cells” are common.
- soccer-ball ✔
- basketball
- football
- tennis-ball
- Which of the following forms of Hb molecule has the lowest affinity for oxygen?
- Tense ✔
- Relaxed
- Arterial
- Venous
- What is the recommended cleaner for removing all oil from objective lens ?
- 70 % alcohol or lens cleaner ✔
- Xylene
- Water
- Benzene
- Intravascular hemolysis is the result of trauma to RBCs while in the circulation
- True ✔
- False
- A 1:20 dilution was made in a unopette, with glacial acetic acid as the diluent. The four corner squares on BOTH sides of the hemacytometer are counted for a total of 100 cells. What is the total WBC (x10^9/L.?
- 0.25
- 2.5 ✔
- 5
- 10
- The shape of a cell is maintained by which of the following?
- Microtubules ✔
- Spindle Fibers
- Ribosomes
- Centrioles
- At which month of fetal development does the bone marrow ecome the primary site of hematopoiesis ?
- 2nd
- 5th
- End of 6th month ✔
- End of 7th month
- Which types of cells develop from yolk sacs (Mesoblastic phase) ?
- Hb F, Hg A2, and Hg A
- Gower 1 and Gower 2 Hgb
- Portland Hgb
- Only Erythroblasts ✔
- Normal Adult Hb A contains the following polypeptide chains:
- alpha and beta ✔
- alpha and epsilon
- alpha and delta
- alpha and brotherton
- Allergic reactions are frequently associated with an increase in the prescence of :
- Lymphocytes
- Neutrophils
- Monocytes
- Eosinophils ✔
- Lipid exchange between the RBC membrane and the plasma occurs:
- To replace lost lipids in the membrane ✔
- To provide a mechanism for excretion of lipid-soluble RBC waste products
- To ensure symmetry between the composition of the interior and exterior lipid layers
- To provide lipid-soluble nutrients to the RBC
- After the microscope has been adjusted for Kohler illumination, light intensity should never be regulated by using the…
- Rheostat
- Neutral density filter
- Kohler magnifier
- Condenser ✔
- Which of the followong types of microscopy is valuable in the identification of crystals that are able to rotate light ?
- Compound brightfield
- Darkfield
- Polarizing ✔
- Phase-contrast
- During the Medullary Phase of hematopoietic development, which bone is the first to show hematopoietic activity ?
- Femur
- Iliac Crest
- Skull
- Clavicle ✔
- Given the following values, calculate the RPI Observed reticulocyte count – 6% Hct- 30%
- 2 ✔
- 3
- 4
- 5
- The lipids of the RBC membrane are arranged:
- In chains beneath a protein exoskeleton
- So that the hydrophobic portions are facing the plasma
- In a hexagonal lattice
- In two layers that are not symmetric in composition ✔
- The hexose monophosphate pathway activity increases the RBC source of
- Glucose and lactic acid
- 2,3-BPG and methemoglobin
- NADPH and reduced glutathione ✔
- ATP and other purine metabolites
- Which single feature of normal RBC’s is most responsible for limiting their life span ?
- Loss of mitochondria
- Increased flexibility of the cell membrane
- Reduction of Hb iron
- Loss of nucleus ✔
- In the Iron cycle, the transferrin receptor carries:
- Iron out of duodenal cells from the intestinal lumen
- Iron out of duodenal cells into the plasma
- transferrin-bound iron in the plasma
- transferrin-bound iron into erythrocytes ✔
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